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    GlossaryIonotropic Receptor (Ligand-Gated Ion Channel)

    allows ions to pass through the cell membrane upon activation

    An ionotropic receptor, also known as a ligand-gated ion channel, is a type of receptor that allows ions to pass through the cell membrane in response to the binding of a chemical messenger, such as a neurotransmitter. When the neurotransmitter binds to the receptor, it causes the channel to open, allowing specific ions like sodium, potassium, or calcium to flow into or out of the cell, which can trigger various cellular responses.

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      community Ligand Chem cease trading Pyrilutamide

      in Product  14 upvotes 2 years ago
      Pyrilutamide, a possible hair loss treatment, ceasing to be traded due to patent laws; and the hope that this indicates it may be a legitimate treatment.

      community Dropping RU , not responding..

      in Treatment  6 upvotes 10 months ago
      The user has been using RU58841 for 6 months without noticeable results and is considering dropping it while continuing oral minoxidil, daily dutasteride, and topical minoxidil. Another user suggests visiting a dermatologist to check for other conditions.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 1 week ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 4 months ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.