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    Glossary Metabotropic Receptor

    cell receptor triggering internal signaling via G-protein activation

    A metabotropic receptor is a type of cell surface receptor that, when activated by a neurotransmitter, initiates a cascade of intracellular events through a signaling molecule called a G-protein. Unlike ionotropic receptors, which form ion channels, metabotropic receptors work indirectly to modulate cellular activity, often resulting in longer-lasting and more diverse effects.

    Research 10 of 72

    1. The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2 Experimental physiology · 2023 · 6 citations
    2. Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth EMBO journal · 2018 · 34 citations
    3. Modulating mechanosensory afferent excitability by an atypical mGluR Journal of anatomy · 2015 · 1 citations
    4. A neuroendocrinological perspective on human hair follicle pigmentation Pigment Cell & Melanoma Research · 2010 · 56 citations
    5. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    6. Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals PLoS ONE · 2013 · 25 citations
    7. Relating neurosteroid modulation of inhibitory neurotransmission to behaviour Journal of Neuroendocrinology · 2021 · 18 citations
    8. The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors Drug Metabolism Reviews · 2006 · 219 citations
    9. Efectos de la alteración de los niveles de allopregnanolona durante periodos críticos del neurodesarrollo en la vulnerabilidad al consumo de alcohol 2018
    10. Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice International Journal of Molecular Sciences · 2025 · 4 citations
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