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    Glossary Metabotropic Receptor

    cell receptor triggering internal signaling via G-protein activation

    A metabotropic receptor is a type of cell surface receptor that, when activated by a neurotransmitter, initiates a cascade of intracellular events through a signaling molecule called a G-protein. Unlike ionotropic receptors, which form ion channels, metabotropic receptors work indirectly to modulate cellular activity, often resulting in longer-lasting and more diverse effects.

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    Research 30 of 75

    1. The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2 Experimental physiology · 2023 · 6 citations
    2. Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth EMBO journal · 2018 · 34 citations
    3. Modulating mechanosensory afferent excitability by an atypical mGluR Journal of anatomy · 2015 · 1 citations
    4. A neuroendocrinological perspective on human hair follicle pigmentation Pigment Cell & Melanoma Research · 2010 · 56 citations
    5. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    6. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    7. Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals PLoS ONE · 2013 · 25 citations
    8. Relating neurosteroid modulation of inhibitory neurotransmission to behaviour Journal of Neuroendocrinology · 2021 · 18 citations
    9. The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors Drug Metabolism Reviews · 2006 · 219 citations
    10. Neurosteroids, neuroactive steroids, and symptoms of affective disorders Pharmacology, Biochemistry and Behavior · 2006 · 82 citations
    11. Efectos de la alteración de los niveles de allopregnanolona durante periodos críticos del neurodesarrollo en la vulnerabilidad al consumo de alcohol 2018
    12. Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice International Journal of Molecular Sciences · 2025 · 4 citations
    13. Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity Frontiers in molecular biosciences · 2022 · 3 citations
    14. Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-?1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles Histochemistry and Cell Biology · 2003 · 32 citations
    15. Synaptic‐like vesicles and candidate transduction channels in mechanosensory terminals Journal of Anatomy · 2015 · 11 citations
    16. Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System 2019 · 142 citations
    17. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    18. Calcium regulation of stem cells EMBO reports · 2020 · 25 citations
    19. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations Frontiers in immunology · 2022 · 21 citations
    20. The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair International journal of molecular sciences · 2024 · 1 citations
    21. Neuroendocrinology of the hair follicle: principles and clinical perspectives Trends in Molecular Medicine · 2014 · 98 citations
    22. TRP Channels in Skin Biology and Pathophysiology Pharmaceuticals · 2016 · 124 citations
    23. The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures 2004 · 64 citations
    24. γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress Life sciences · 2023 · 1 citations
    25. Non-pigmentary actions of alpha-melanocyte-stimulating hormone--lessons from the cutaneous melanocortin system. PubMed · 2006 · 16 citations
    26. Growth Hormone and the Human Hair Follicle International journal of molecular sciences · 2021 · 14 citations
    27. Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis European Journal of Pharmacology · 2023 · 7 citations
    28. Glutamic acid promotes hair growth in mice Scientific Reports · 2021 · 12 citations
    29. Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role Current Sexual Health Reports · 2020
    30. Poster Abstracts Fundamental & Clinical Pharmacology · 2017