TLDR Hair samples can reliably monitor tacrolimus levels in kidney transplant patients.
This study quantified tacrolimus levels in the scalp hair of 39 kidney transplant recipients, finding detectable levels in 98% of samples with a median concentration of 7.0 pg/mg. There was a positive, though not statistically significant, correlation between hair tacrolimus levels and daily dose. Hair analysis reflected recent medication changes, suggesting its potential for long-term drug monitoring. The study noted that hair color and patient age significantly influenced tacrolimus levels, with higher concentrations in darker hair and lower levels in older patients. Despite the small cohort and single-time point evaluations, the method offers a non-invasive alternative for therapeutic drug monitoring. Further research is needed to establish therapeutic targets and understand confounders.
97 citations,
January 2020 in “Advances in chronic kidney disease” Calcineurin inhibitors, used in kidney transplants, can cause a wide range of side effects including kidney damage and other health issues.
7 citations,
January 2019 in “Journal of Analytical Toxicology” Tramadol and THC-COOH can be detected in hair for several months after stopping use.
19 citations,
January 2015 in “Current problems in dermatology” Ultraviolet rays damage hair, smoking may cause hair loss, and good nutrition is important for hair health, but genetics mainly decide hair thickness.
12 citations,
November 2014 in “Journal of Cutaneous Medicine and Surgery” Antiviral medication valganciclovir may improve skin and hair in Trichodysplasia Spinulosa patients.
3 citations,
July 2017 in “Elsevier eBooks” Skin reactions are a common reason for emergency visits due to drug allergies, with some severe cases needing intensive care.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
85 citations,
October 2012 in “Dermatologic Clinics” Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.
