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Glossary Lichen Planopilaris

rare inflammatory condition causing scarring and permanent hair loss

Lichen Planopilaris (LPP) is a rare inflammatory condition that affects the hair follicles, leading to scarring and permanent hair loss. It is a form of lichen planus that specifically targets the scalp, causing symptoms such as redness, itching, and scaling. Early diagnosis and treatment are crucial to prevent extensive hair loss.

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Research

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research Postmenopausal frontal fibrosing alopecia: A frontal variant of lichen planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

This study reports that progressive frontal fibrosing alopecia, a distinct and gradually stabilizing form of lichen planopilaris affecting elderly women and often involving eyebrow hair loss, lacks effective treatments.

research Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research Lichen Planopilaris: Update on Diagnosis and Treatment

160 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

This article reviews lichen planopilaris, its presentation, and treatment challenges, and emphasizes the need for more research into its pathogenesis and therapy efficacy; it reports no new findings.

research Lichen planus

155 citations , June 2009 in “International Journal of Dermatology”

This extensive review discusses the clinical manifestations, potential associations, and treatment approaches for lichen planus, but reports no new clinical results, highlighting gaps in evidence for therapeutic strategies.

research Frontal fibrosing alopecia versus lichen planopilaris: a clinicopathological study

126 citations , April 2006 in “International Journal of Dermatology”

This study found that frontal fibrosing alopecia and lichen planopilaris have similar histopathological features, but FFA exhibits more prominent apoptosis and less inflammation with spared interfollicular epidermis.

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community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Losing Hair on Dutasteride? You might have LPP

96 upvotes 1 year ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What are all the blood work that can be checked for potential causes of hair loss?

in Research/Science 6 upvotes 1 year ago

The conversation is about potential causes of hair loss and treatments, including topical and oral minoxidil, finasteride, and dutasteride, with a focus on checking for vitamin deficiencies and conditions like Lichen Planopolaris. It also discusses the skepticism around certain tests and the success of hair transplants.

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