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    Glossary Janus Kinase

    enzyme involved in cell signaling and immune response

    Janus Kinase (JAK) is a type of enzyme that plays a crucial role in the signaling pathways of cells, particularly in the immune system. It helps transmit signals from various cytokines and growth factors to the cell nucleus, influencing cell growth, survival, development, and differentiation. Dysregulation of JAK activity is associated with various diseases, including certain types of alopecia and autoimmune disorders, making it a target for specific therapeutic drugs known as JAK inhibitors.

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    1. Targeting the Janus Kinase Family in Autoimmune Skin Diseases Frontiers in Immunology · 2019 · 124 citations
    2. Role of janus kinase inhibitors in the treatment of alopecia areata Drug design, development and therapy · 2018 · 53 citations
    3. Inhibiting Janus kinases to treat alopecia areata Nature medicine · 2014 · 52 citations
    4. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    5. The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019 · 17 citations
    6. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    7. The relative efficacy of monotherapy with Janus kinase inhibitors, dupilumab and apremilast in adults with alopecia areata: Network meta‐analyses of clinical trials Journal of cosmetic dermatology · 2023 · 2 citations
    8. Janus Kinase Inhibitors in the Treatment of Alopecia Areata Prague Medical Report · 2023 · 2 citations
    9. Novel Janus Kinase Inhibitors in the Treatment of Dermatologic Conditions 2023 · 1 citations
    10. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
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