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    Glossary Janus Kinase

    enzyme involved in cell signaling and immune response

    Janus Kinase (JAK) is a type of enzyme that plays a crucial role in the signaling pathways of cells, particularly in the immune system. It helps transmit signals from various cytokines and growth factors to the cell nucleus, influencing cell growth, survival, development, and differentiation. Dysregulation of JAK activity is associated with various diseases, including certain types of alopecia and autoimmune disorders, making it a target for specific therapeutic drugs known as JAK inhibitors.

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    1. Targeting the Janus Kinase Family in Autoimmune Skin Diseases Frontiers in Immunology · 2019 · 124 citations
    2. Role of janus kinase inhibitors in the treatment of alopecia areata Drug design, development and therapy · 2018 · 53 citations
    3. Inhibiting Janus kinases to treat alopecia areata Nature medicine · 2014 · 52 citations
    4. The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019 · 17 citations
    5. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    6. The relative efficacy of monotherapy with Janus kinase inhibitors, dupilumab and apremilast in adults with alopecia areata: Network meta‐analyses of clinical trials Journal of cosmetic dermatology · 2023 · 2 citations
    7. Janus Kinase Inhibitors in the Treatment of Alopecia Areata Prague Medical Report · 2023 · 2 citations
    8. Novel Janus Kinase Inhibitors in the Treatment of Dermatologic Conditions 2023 · 1 citations
    9. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    10. The role of janus kinases in the treatment of autoimmune skin diseases Farmacja Polska · 2021 · 1 citations
    11. Perspectives of Chinese Adult Patients with Alopecia Areata on Janus Kinase Inhibitors Therapy: A Qualitative Analysis Based on Social Media Platforms Patient Preference and Adherence · 2025
    12. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    13. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    14. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    15. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    16. Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata Skin health and disease · 2023 · 4 citations
    17. Janus kinase inhibitors for alopecia areata: A narrative review Indian journal of dermatology, venereology, and leprology · 2023 · 2 citations
    18. The Role of Janus Kinase Inhibitors in Dermatology Eduvest - Journal Of Universal Studies · 2026
    19. P718 Observational real-world evidence on the efficacy and safety of Janus Kinase inhibitors (JAKi) in the treatment of moderate to severe Active Ulcerative Colitis (UC) Journal of Crohn's and colitis · 2024
    20. Janus kinase inhibitors in dermatology: A systematic review Journal of the American Academy of Dermatology · 2017 · 116 citations
    21. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    22. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018 · 66 citations
    23. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    24. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    25. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    26. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    27. Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata JAAD case reports · 2019 · 32 citations
    28. Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis Journal of the European Academy of Dermatology and Venereology · 2024 · 20 citations
    29. The role of Janus kinase inhibitors in the treatment of alopecia areata: A systematic review Dermatologic therapy · 2019 · 19 citations
    30. Janus kinase inhibition for the treatment of refractory frontal fibrosing alopecia: A case series and review of the literature JAAD Case Reports · 2023 · 16 citations