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Glossary Ionizing Radiation

high-energy particles or waves that can remove electrons from atoms

Ionizing radiation (IR) refers to high-energy particles or waves, such as X-rays, gamma rays, and certain particles, that have enough energy to remove tightly bound electrons from atoms, creating ions. This process can damage or alter the DNA in cells, which is why it is used in medical imaging and cancer treatment, but also why it poses risks such as radiation sickness and increased cancer risk with excessive exposure.

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research A simple assay for the study of human hair follicle damage induced by ionizing irradiation

16 citations , November 2009 in “Experimental dermatology”

This study found that ionizing irradiation significantly inhibits proliferation and induces apoptosis in human hair follicle keratinocytes, suggesting its potential as a preclinical assay system for testing radioprotectants.

research Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

January 2024 in “GeroScience”

This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.

research p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss

37 citations , April 2010 in “FEBS Letters”

In this study, researchers reported that the activation of EDA2R by p53 leads to p53-dependent cell death in cancer cells and is involved in chemotherapy-induced hair loss.

research Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

14 citations , January 2014 in “Cells Tissues Organs”

This study found that single high-dose irradiation in mice induced more severe acute skin injury and hair depigmentation, while fractional doses led to longer-term damage in the dermis and subcutis.

research Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury

4 citations , August 2022 in “International Journal of Molecular Sciences”

This study found that cultured foreskin is not suitable for studying H2A.J-related tissue changes during radiation-induced dermatitis due to existing high H2A.J expression and cytokine secretion even without irradiation.

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