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research Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors

24 citations , September 2014 in “PloS one”

This study demonstrated that thyroid hormone receptors play a crucial role in hair growth and skin health, as mice lacking these receptors showed impaired hair cycling and wound healing.

research Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier

23 citations , March 2017 in “Journal of Investigative Dermatology”

An artificial lipid barrier can restore hair growth in cases of SCD1 deficiency.

research Effects of vitamin A deficiency on skin and hair growth in mice

3 citations , March 1956 in “Journal of morphology”

This study found that vitamin A deficiency in mice led to impaired skin and hair growth.

research Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia

December 2023

This study found that androgenetic alopecia patients exhibited impaired arginine metabolism in balding hair follicles, suggesting that arginine supplementation may help preserve hair growth by counteracting mTOR signaling pathway disruption and offering potential as a treatment strategy.

research Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity

June 2023 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

In this study, researchers found that knockdown of ABCA5 in primary human hair follicle keratinocytes disrupted cholesterol homeostasis and transportation, suggesting its potential role in hair growth disorders by affecting intracellular cholesterol compartmentalization and LXR-mediated transcriptional activity.

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Community Join

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Serum based on plant extracts boosts hair growth in weeks.

44 upvotes 11 months ago

A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

community Can liver problems be associated with response to the oral minoxidil?

in Research 147 upvotes 8 months ago

Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

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Clinics

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Learn

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learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn Vascular Endothelial Growth Factor

Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Unproven. Raising VEGF increases vessels around follicles in mice and minoxidil raises VEGF in cultured cells, but no study shows VEGF-marketed products improve scalp blood flow or hair loss in people.

learn Selenium

Can Selenium supplements help prevent or reverse hair loss caused by nutritional deficiencies? Evidence that selenium helps hair comes mainly from rare, severe deficiency, such as long-term intravenous feeding without selenium. Extra selenium has not been shown to help people who are not deficient, and intake above 400 µg a day can cause hair loss.

learn Keratin

Are keratin treatments good for people with alopecia, or do they only improve the hair’s appearance? Keratin treatments improve hair appearance but do not address alopecia or stimulate growth.

learn KY19382

Experimental compound that activates hair-growth signals, tested only in animals

learn Procyanidin

Are Procyanidin based hair tonics or shampoos effective against androgenic alopecia? Three small trials of topical procyanidin in 29 to 43 men, all run by the company that developed it, reported modest hair-count gains after four to six months. No independent trial has confirmed them, and procyanidin is not an approved treatment for pattern hair loss.

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Osteopontin

Signalling protein studied in hair-growth research

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