In this research, an optimized protocol was developed for dissociating humanscalptissue to produce high-quality single-cell suspensions suitable for single-cell RNA sequencing, aimed at studying the transcriptomics of human hair follicles.
14 citations
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February 2020 in “Scientific reports”
This study found that telocytes in humanscalptissue were located around hair follicles and glands and may be involved in skin regeneration and homeostasis.
June 2014 in “Biotechnology and Bioprocess Engineering”
This study demonstrated that injecting reconstructed dermal papilla-like tissues in mice led to new hair growth, suggesting potential future applications in hair transplantation and baldness treatment.
4 citations
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April 2022 in “Dermatologic Therapy”
This study found that using autologous micrografts from scalptissues significantly improved hair thickness and density in patients experiencing telogen effluvium following COVID-19, with notable improvements observed over a 6-month follow-up period.
Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.
Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.
Verteporfin is being discussed for its potential to regrow hair and heal scars, possibly aiding hair transplants or replacing them. Some users are skeptical about its effectiveness, while others suggest combining it with microneedling for better results.
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
Is Osteopontin more effective in topical treatments or oral supplements for hair loss?Neither route has been tested: there is no published human trial of topical or oral osteopontin for hair loss. The evidence is preclinical, and it points both ways — injected osteopontin promoted hair growth in mice, while an osteopontin-derived peptide suppressed growth in human scalp tissue and is being developed to remove unwanted hair.
What results can you expect from using bicalutamide on your scalp?There is no published human study of bicalutamide applied to the scalp for hair loss, no licensed topical product and no established dose, so no result can be predicted from it. The evidence that exists is for the oral tablet in women, which is a prescription drug requiring liver monitoring and contraindicated in pregnancy.
Is rapamycin safe for long-term use on the scalp, or should it be used in cycles?There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.
Can latanoprost be safely applied to the scalp, or is it only for eyelashes?Latanoprost is not approved for use on the scalp and its safety there has not been established: the only human scalp evidence is one 24-week pilot trial in 16 men, and clinicians flag irritation, skin darkening and unknown absorption over a large area as open risks.
How does capsicum improve scalp circulation and boost growth?Capsaicin dilates blood vessels through TRPV1 activation, so capsicum is expected to raise scalp blood flow, but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.