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research To grow or not to grow: Hair morphogenesis and human genetic hair disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

This mini-review discusses human hair follicle development and summarizes genetic disorders linked to abnormalities in hair follicle morphogenesis, structure, or regeneration, but reports no new experimental results.

research Mimicking Hair Disorders by Genetic Manipulation of Organ-Cultured Human Hair Follicles

5 citations , September 2012 in “Journal of Investigative Dermatology”

This study found that knocking down P-cadherin expression in cultured human hair follicles recreates the hair abnormalities seen in patients with hypotrichosis with juvenile macular dystrophy.

research Lanceolate hair-J (lah^J ): A mouse model for human hair disorders

37 citations , June 2000 in “Experimental dermatology”

This study investigated a spontaneous mutation in mice resulting in hair abnormalities and elevated IgE levels, which resembles human Netherton's syndrome and monilethrix.

research Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment

2 citations , January 2014 in “Hair therapy & transplantation”

This review explores the molecular controls of hair follicle cycling and highlights the challenge of developing effective treatments for common hair disorders without providing new clinical results.

research PATHOGENESIS OF GENETIC HUMAN HAIR DISORDERS

1 citations , August 1981 in “The Journal of Dermatology”

This study reported that defects in the hair cuticle were found in every case of major structural hair abnormalities examined.

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Community Join

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community Hair Loss Causes Depression. Not Finasteride.

187 upvotes 7 months ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.

community Why is god NOT ashamed of cursing me with this disorder and making me sensitive to all the meds that work

34 upvotes 1 month ago

The conversation discusses hair loss treatments like Minoxidil and Finasteride, with users sharing experiences and suggesting alternatives like topical applications and hair systems. It also touches on personal beliefs and perspectives on faith and life challenges.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Natural sweetener Stevia found to turbocharge male pattern baldness treatment: Mice given Stevia patch had 18 times better absorption of minoxidil and hair coverage of 67.5% in bald areas after just 35 days.

1741 upvotes 9 months ago

Stevia microneedles increased minoxidil absorption and hair growth in mice. The conversation humorously questions the applicability of these results to humans.

community 2 % fucoidan significantly alleviated AGA symptoms, promoted hair growth, and increased hair density

21 upvotes 11 months ago

2% fucoidan alleviated AGA symptoms, promoted hair growth, and increased hair density in mice. Fucoidan is considered safe for humans as a supplement and topical skincare product, with potential therapeutic effects against AGA.

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Learn

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learn Castor oil

A plant oil used in cosmetics and traditional medicine. It is popular in hair care, but no controlled human trial has tested it as a hair-growth treatment.

Does castor oil make hair grow or is it just a myth? There is no published human trial showing castor oil grows hair. It can make hair look and feel better by reducing breakage and adding shine, which is easily mistaken for growth, and it is not approved anywhere as a hair loss treatment.

learn Vitamin D

Low vitamin D is linked with some types of hair loss, especially alopecia areata, but there is no good evidence that supplements help hair unless you are deficient. Ask a doctor about a blood test before you supplement.

learn Valproic acid

a prescription anticonvulsant and known teratogen that has been studied experimentally for hair loss; oral valproate commonly causes hair loss

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn RU58841

Will I lose my hair if I stop using RU58841? (Spoiler: I might.) There is no published human trial of stopping RU58841; community members commonly report shedding within weeks to months, and androgen biology suggests miniaturization would resume once the topical anti-androgen is withdrawn.

learn Redensyl

Does Redensyl prevent hair loss or only help when there's already visible hair loss? The only human data on Redensyl is a small, unpublished manufacturer study in men who already had androgenetic alopecia; there is no evidence in people without visible hair loss, so nothing supports using it to prevent hair loss before it starts.

learn Ecklonia Cava

Can Ecklonia Cava be used as a preventive treatment for early signs of hair thinning? No human trial has tested Ecklonia cava for hair loss, so it cannot be called preventive; the evidence is mouse studies and cell cultures suggesting antioxidant activity and 5-alpha-reductase inhibition in the lab.

learn Sulforaphane

How often should sulforaphane-based products be used for hair loss prevention? No human trial has tested sulforaphane for hair loss prevention, so there is no established usage frequency. Oral supplements are taken daily in research on unrelated conditions and the hair-specific evidence is limited to cell, mouse and isolated-follicle studies, so any schedule is extrapolation rather than a dosing guideline.

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Clinics

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Trichology
The Pharmacy for Hair Loss & Scalp Disorders, PLLC.Brentwood, TN · US

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