Pathogenesis of Genetic Human Hair Disorders

    August 1981 in “ The Journal of Dermatology ”
    Takashi Aoyagi, Yusho Miura, Paul S. Porter
    TLDR All major hair defects involve cuticle abnormalities.
    The document discussed several distinct morphological abnormalities of hair, focusing on congenital hair defects related to anatomical issues, such as defective cuticle formation, and biochemical properties, like reduced sulfur content. The major structural hair abnormalities identified included defects in the cuticle, cortex, and medulla, with cuticle defects present in each case of a major structural hair defect.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I was on 2.5 mg oral minoxidil

      in Progress Pictures  468 upvotes 1 year ago
      User took 2.5 mg oral minoxidil, saw hair growth but stopped due to excessive body hair. Recently started finasteride and plans to update progress.

      community Hair loss research is a money grab

      in Chat  217 upvotes 1 month ago
      Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

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