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GlossaryHLA-DQ

protein complex involved in immune system antigen presentation

HLA-DQ is a protein complex that plays a crucial role in the immune system by helping the body distinguish between its own cells and foreign invaders. It is part of the human leukocyte antigen (HLA) system, specifically involved in presenting antigens to immune cells, which is essential for initiating an immune response. Variations in HLA-DQ genes are associated with susceptibility to certain autoimmune diseases, including type 1 diabetes and celiac disease.

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research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations, August 2005 in “Autoimmunity Reviews”

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

research Identification of Drug-Specific Public TCR Driving Severe Cutaneous Adverse Reactions

88 citations, August 2019 in “Nature communications”

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

research Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

24 citations, January 2008 in “KARGER eBooks”

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

research Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis

15 citations, April 2003 in “Journal of dermatology”

Alopecia areata causes hair loss due to an immune attack on hair follicles, influenced by genetics and environment.

research Alopecia Areata: Medical Treatments

3 citations, January 2015 in “Nasza Dermatologia Online”

Some treatments for autoimmune hair loss work, but JAK inhibitors like tofacitinib are promising for regrowth.

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