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Glossary GGN Repeats

specific DNA sequence repeated within certain genes

GGN repeats refer to a specific sequence of nucleotides (guanine-guanine-nucleotide) that are repeated multiple times within a gene. These repeats can influence the function of the gene and are often studied in the context of genetic disorders and variations. For example, variations in the number of GGN repeats in the androgen receptor gene can affect its activity and have been linked to conditions like androgenic alopecia (male pattern baldness).

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research Polymorphism of CAG and GGN repeats of androgen receptor gene in women with polycystic ovary syndrome

9 citations , September 2015 in “Reproductive Biomedicine Online”

This study suggests that longer GGN repeat polymorphisms in the androgen receptor gene are associated with polycystic ovary syndrome in women.

research Androgen receptor gene CAG and GGN polymorphisms in infertile Nigerian men

26 citations , November 2009 in “Journal of Endocrinological Investigation”

This study found no significant difference in the CAG and GGN repeat lengths between infertile and fertile men in Nigeria, but identified a unique GGN allele distribution in the Nigerian population compared to Caucasians.

research The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals

9 citations , March 2009 in “Psychoneuroendocrinology”

This study found that variations in the androgen receptor gene influenced memory function in women, with GGN repeat polymorphisms significantly affecting logical memory performance only in females.

Androgen Receptor Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males with Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

research Androgen receptor (AR) gene (CAG)n and (GGN)n length polymorphisms and symptoms in young males with long-lasting adverse effects after finasteride use against androgenic alopecia

March 2017 in “European Urology Supplements”

This study found that variations in (CAG)n and (GGN)n polymorphisms in the androgen receptor gene appear to influence symptom severity in men with post-finasteride syndrome.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

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