Androgen Receptor Gene CAG and GGN Polymorphisms in Infertile Nigerian Men

    November 2009 in “ Journal of Endocrinological Investigation ”
    Oluyemi Akinloye, Jörg Gromoll, Eberhard Nieschlag, Manuela Simoni
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    TLDR Certain gene variations are not a major cause of male infertility in Nigerian men.
    The study examined the association between androgen receptor gene polymorphisms (CAG and GGN repeats) and male infertility in a Nigerian population, including 60 infertile men (20 with non-obstructive azoospermia and 40 with oligozoospermia) and 38 fertile controls, as well as 48 German volunteers for comparison. The results indicated no significant difference in the length of CAG and GGN repeats between the infertile and fertile Nigerian men. Although a unique distribution of GGN alleles was observed in the Nigerian population, with 20-23 repeats being predominant and different from the Caucasian population, the study concluded that CAG and GGN repeat polymorphisms are not a significant factor in male infertility in the Nigerian population. However, the unique distribution of GGN alleles in Nigerians compared to Caucasians suggests the need for further research.
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