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Glossary Follicle Depth

distance from skin surface to hair follicle base

Follicle depth refers to the distance from the surface of the skin to the base of the hair follicle, where hair growth begins. This measurement is important for understanding hair growth patterns, diagnosing conditions like alopecia, and planning treatments such as hair transplants.

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Research

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research A systematic summary of survival and death signalling during the life of hair follicle stem cells

31 citations , August 2021 in “Stem Cell Research & Therapy”

This review examines the life cycle, biomarkers, and functions of hair follicle stem cells, emphasizing their role in hair loss therapy and other skin and hair disorders, but reports no new clinical results.

research Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations , June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.

research Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride

2 citations , January 2019 in “Indian Journal of Pharmaceutical Sciences”

This study found that higher doses of zinc increased cell growth but also induced cell death in human follicle dermal papilla cells, suggesting a narrow dosage range may affect hair regrowth.

research 1391 Cell death functions in hair follicle regeneration

April 2023 in “Journal of Investigative Dermatology”

This study found that blocking apoptosis during the catagen phase in mice disrupts hair follicle stem cell niche architecture, delaying subsequent hair regeneration cycles.

research Time and depth resolved visualisation of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin

36 citations , July 2004 in “Journal of Controlled Release”

This study demonstrates that confocal laser scanning microscopy can effectively visualize the rapid diffusion and penetration pathway of a dye into the hair follicle in fresh human scalp skin.

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Community Join

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community Microneedling and miniaturized hair follicles depth

in Microneedling 8 upvotes 1 year ago

Microneedling at depths greater than 0.6 mm may damage miniaturized hair follicles, with 0.5 mm showing better results for hair regrowth. Combining microneedling with minoxidil enhances absorption, but caution is advised to avoid damaging follicles.

community Losing Hair from Microneedling?

4 upvotes 3 weeks ago

Microneedling can cause hair shedding due to follicle puncturing, especially when using a 1mm depth. Users suggest using a dermastamp with a depth of 0.6-1mm and caution against home microneedling to avoid damaging hair follicles.

community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

23 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community Is microneedling worth it when you're on dut and oral min?

in Microneedling 11 upvotes 7 months ago

Microneedling may not significantly enhance hair growth when combined with dutasteride and oral minoxidil, as its primary benefit is improving topical absorption. Some users suggest using a 1.5mm depth for potential follicle stimulation, but results and effectiveness vary.

community Can microneedling damage existing hair?

in Microneedling 9 upvotes 1 year ago

Microneedling is unlikely to damage existing hair if done with a device using a smaller needle count, like a 9-needle cartridge, and a stamping motion. Hair follicles are deeper than the typical needle penetration depth.

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Learn

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Dexpanthenol

Provitamin B5, a moisturiser in hair and skin products

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

learn Ketoconazole

Antifungal, best known as a dandruff shampoo

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Providers say SMP sits above the hair follicles and does not harm them. No study has tested this, and infection or scarring from any tattoo can affect the skin.

learn Redensyl

Does Redensyl regenerate follicles or only strengthen existing hair? No independent study has shown that Redensyl regenerates follicles or strengthens hair; the only human data are a small, unpublished manufacturer study.

learn Fluridil

Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men; placebo-controlled for 3 months, then all on fluridil to 9 months) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.

learn PP405

Is PP405 a peptide that protects follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.

learn Exosomes

Can an exosome treatment revive hair follicles that have stopped producing hair? Unproven. No controlled human study shows that exosomes revive dormant follicles, none can revive scarred ones, and no exosome product is FDA-approved.

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