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research Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation

29 citations , July 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that in mouse hair follicles, enzymes Aldh1a2 and Aldh1a3 have distinct expression patterns that suggest they are involved in different signaling pathways during the hair cycle.

research Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex

47 citations , June 2009 in “Journal of Biological Chemistry”

This study found that finasteride competitively inhibits the enzyme AKR1D1 with low micromolar affinity but does not act as a mechanism-based inactivator.

research Effects of combined use of keratinolytic enzymes and sugarcane fibre on the hairball excretion in cats

3 citations , August 2019 in “Journal of Animal Physiology and Animal Nutrition”

This study found that the combined use of sugarcane fibre and keratinolytic enzymes reduced hairball excretion in cats.

research Complémentarité et équilibre de l’apport alimentaire en protéines et en lipides

5 citations , January 2003 in “Oilseeds and fats, crops and lipids/OCL. Oilseeds & fats crops and lipids”

This review discusses the effects of dietary protein and its components on cholesterol, essential fatty acids, and possible health consequences, but presents no new clinical findings.

research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs

1 citations , February 2014 in “Archiv Der Pharmazie”

This study demonstrated that steroidal carbamates 7–10 altered mRNA expression related to lipid metabolism in hamster flank organs and inhibited 5α-reductase activity without binding to the progesterone receptor.

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community Complete non responder to everything. Modern Norwood Sisyphus

78 upvotes 1 year ago

The user has been using finasteride for four years and topical minoxidil with microneedling for a year but has not seen significant results in slowing hair loss. They are considering trying dutasteride despite concerns about its intensity, and others suggest trying oral minoxidil or combining treatments for better results.

community MinoxiBoost - SULT1A1 Enzyme booster journey

in Minoxidil 7 upvotes 2 years ago

The user has tried topical Minoxidil and oral Minoxidil for beard and scalp hair growth with minimal results, and has been on Finasteride for 7 months with stabilized scalp hair but no facial hair improvement. They are considering using a SULT1A1 enzyme booster to enhance results and are questioning its effectiveness without concurrent topical Minoxidil application.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community If OpenAI finds a cure for balding I hereby swear I will dedicate the rest of my life to converting saltwater into freshwater

278 upvotes 2 weeks ago

The conversation discusses the complexity of finding a cure for hair loss, mentioning treatments like finasteride, dutasteride, and potential future solutions involving AI. It highlights skepticism about a quick solution due to testing and approval processes, while some users express hope in AI's potential to develop effective treatments.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 1 year ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

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