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GlossaryGenetic Variants (DNA Polymorphisms)

differences in DNA sequence among individuals

Genetic variants, also known as genetic polymorphisms, are differences in the DNA sequence among individuals. These variations can affect how genes function and can influence traits such as hair color, susceptibility to diseases like alopecia, and response to medications. While some genetic variants have no impact on health, others can be significant in understanding genetic predispositions and developing personalized medical treatments.

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research The Gene for Autosomal Dominant Hidrotic Ectodermal Dysplasia (Clouston Syndrome) in a Large Indian Family Maps to the 13q11-q12.1 Pericentromeric Region

39 citations, July 1997 in “American Journal of Medical Genetics”

The gene for Clouston syndrome in a large Indian family is located in the 13q11-q12.1 region.

research DNA Phenotyping: Current Application in Forensic Science

11 citations, February 2019 in “Research and reports in forensic medical science”

DNA phenotyping helps predict physical traits from DNA with varying accuracy and requires careful ethical and legal handling.

Cloning of the Human Phenol Sulfotransferase Gene Family: Three Genes Implicated in the Metabolism of Catecholamines, Thyroid Hormones, and Drugs

research Cloning of the Human Phenol Sulfotransferase Gene Family: Three Genes Implicated in the Metabolism of Catecholamines, Thyroid Hormones, and Drugs

26 citations, February 1998 in “Chemico-Biological Interactions”

Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

research Association of mtDNA M/N Haplogroups with Systemic Lupus Erythematosus: A Case-Control Study of Han Chinese Women

11 citations, June 2015 in “Scientific Reports”

The mtDNA N haplogroup is linked to a higher risk of late-onset lupus and specific symptoms in Han Chinese women.

research Vitamin D Resistance: Tissue Resistance to Vitamin D and Vitamin D-Dependent Rickets Types I and II

13 citations, April 1994 in “Baillière's clinical endocrinology and metabolism”

Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.

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community DNA Trichotest reliable? & topical spironolactone for Cis males

in Research/Science 1 upvotes 2 months ago

The DNA Trichotest is considered unreliable for predicting hair loss treatment responses, and topical spironolactone is questioned for its effectiveness and safety in cis males. Finasteride and Dutasteride are recommended as more reliable treatments for androgenic alopecia.

community DNA Testing by Roots by Genetic Arts

in Research/Science 3 upvotes 9 months ago

A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

community Topical Melatonin for mild aga

in Chat 2 upvotes 9 months ago

The conversation is about an 18-year-old male considering topical finasteride for hair loss and asking about the effectiveness of topical melatonin for hair regrowth and density. No specific treatments were confirmed to be used.

community Trichotest results in… min not on my list! Just Fin/Dut, Zinc… and the insanely expensive latanoprost & prostaquinon.

in Technology 22 upvotes 2 years ago

Hair loss discussion includes treatments like hinoki tree oil and procyanidin b2. Experiences and effectiveness of these treatments are shared.

community Bryan Johnson used a customized formula by Roots byGA to restore his hair

in Treatment 23 upvotes 1 month ago

Bryan Johnson used a customized hair restoration formula from Roots byGA, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. Many users are skeptical of the effectiveness and uniqueness of the treatment, suggesting that standard treatments like Minoxidil and Dutasteride are more reliable.

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