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      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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      research Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant

      October 2024 in “Frontiers in Immunology”
      This study investigates the link between nasopharyngeal Bordetella pertussis colonization and alopecia areata (AA) using an intranasal sensitization model in mice. Researchers found that administering pertussis toxin (PTx) and myelin oligodendrocyte peptide (MOG35-55) led to 36.4% of mice developing patchy alopecia, characterized by a shift from anagen to telogen phase hair follicles and increased T cell infiltration. The study suggests that subclinical BP colonization could contribute to AA, highlighting PTx's role as an adjuvant in autoimmune disease models and proposing a novel animal model for studying AA.
      Pathophysiology of Behçet's Disease

      research Pathophysiology of Behçet's Disease

      34 citations , October 2011 in “Pathology Research International”
      Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

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