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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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5 / 1000+ resultsresearch A Comprehensive Investigation Into the Molecular Mechanism Responsible for Selective Androgen Receptor Modulator Tissue-Selectivity
The study investigated the molecular mechanism behind the tissue-selectivity of selective androgen receptor modulators (SARMs) by analyzing the conformation of the androgen receptor (AR) using various techniques. Despite initial challenges with biotinylation, further analysis revealed ligand-specific cofactors, notably identifying nuclear receptor corepressor (NCoR) exclusively in SARM-treated samples. This was confirmed by observing a higher degree of AR-SARM/NCoR association compared to AR-DHT/NCoR. Additionally, differences in cytoplasmic-nuclear transport and nuclear foci formation between AR-SARM and AR-DHT were noted. The findings suggested that AR-SARM complexes have distinct structural and functional properties, providing insights into the SARM tissue-selective mechanism and potential research directions.
research Novel PAX9 Mutation Associated with Syndromic Tooth Agenesis
A new PAX9 gene mutation causes missing teeth and hair problems, but not skin or nail issues.
research Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and Pilomatricoma
The genes OVOL1 and OVOL2 are important for hair growth and may be involved in a type of skin tumor.
research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities
The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway
Lef1 helps stem cells become hair cells by interacting with specific signaling pathways.
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5 / 5 resultscommunity PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
community Blaming Finasteride doesn't help you solve anything: dry eyes
Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.
community Does melatonin dissolve in isopropyl alcohol
The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.
community Why does this industry still revolve around 5-AR inhibitors?
Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.
community PP405 Identity Research
PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.