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Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
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Tracking 13 products like 96 MinoDuta, 16 Oral Finasteride, 107 MINOXIDIL SHAMPOO FR-S1, 117 REGROWTH LABS M7A TRICHOGEN and 118 REGROWTH LABS 7HP from by companies like MinoxidilMax, Hims and Minoxidil Express. View all 13 products »Learn
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research compound made to degrade androgen receptors in scalp
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the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil
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a natural and far less effective alternative to Finasteride
Research
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research Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface
Blocking a specific protein signal can make hair grow on mouse nipples.
research Conversion of C57Bl/6 Mice from a Tumor Promotion-Resistant to a Sensitive Phenotype by Enhanced Ornithine Decarboxylase Expression
A transgenic mouse model was developed to overexpress ornithine decarboxylase (ODC) specifically in hair follicle keratinocytes using a regulated system. In the absence of doxycycline, these mice showed high levels of epidermal ODC activity and hyperplasia when exposed to the tumor promoter TPA, particularly affecting hair follicles. This effect was reversed by adding doxycycline, which repressed transgene expression. The study found that increased ODC expression made the typically tumor promotion-resistant C57Bl/6 mice more sensitive to TPA's effects, as evidenced by a reduction in papilloma development when ODC expression was repressed.
research Conversion of C57Bl/6 Mice from a Tumor Promotion-Resistant to a Sensitive Phenotype by Enhanced Ornithine Decarboxylase Expression
The study developed a transgenic mouse model to investigate the role of ornithine decarboxylase (ODC) in tumor promotion. By using a tetracycline-regulated system, researchers were able to overexpress ODC specifically in hair follicle keratinocytes of C57Bl/6 mice. In the absence of doxycycline, these mice showed high levels of epidermal ODC activity and hyperplasia when exposed to the tumor promoter TPA, particularly affecting hair follicles. This increased ODC expression made the typically tumor-resistant C57Bl/6 mice more sensitive to tumor-promoting effects. However, when doxycycline was used to repress ODC expression, the number of papillomas was significantly reduced, demonstrating the critical role of ODC in tumor promotion.
research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair
Fat cells in the skin help start healing and form important repair cells after injury.
research Coarse to Fine Hair Conversion Induced by Zinc in C57/6J Mice
Zinc made mice's coarse hair turn into fine hair without affecting skin structure.
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5 / 1000+ resultscommunity Tretinoin for increased minoxidil conversion
The conversation is about using Tretinoin with Minoxidil for hair loss treatment, discussing the effectiveness and personal experiences with different concentrations. The image linked in the post received negative reactions for being unpleasant.
community Dr. Kyle Gillet on Dr. Andrew Huberman's podcast said dutasteride mesotherapy blocks DHT conversion only in the scalp and called it the most promising topical currently. What's the scoop?
Dr. Kyle Gillet mentioned on Dr. Andrew Huberman's podcast that dutasteride mesotherapy blocks DHT conversion only in the scalp and is the most promising topical treatment. Users discussed concerns about systemic absorption and the practicality of dutasteride injections.
community Theory As To Why Oral Minoxidil Might Be Helpful To People Compared To Topical Minoxidil
Oral minoxidil may be more effective than topical due to uniform distribution and systemic activation, but can cause side effects like puffiness. Adding tretinoin to topical minoxidil can enhance its effectiveness by aiding conversion to its active form.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Mechanism of action of alfatradiol (17 alpha estradiol)
The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.