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    Did you mean Caspase-1?
    Glossary Caspase-1

    enzyme activating inflammatory cytokines and inducing cell death

    Caspase-1, also known as Interleukin-1 converting enzyme (ICE), is an enzyme that plays a crucial role in the inflammatory response by activating pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). It is also involved in a form of programmed cell death called pyroptosis, which helps the body fight infections by eliminating infected cells.

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    1. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice Journal of Immunology · 2015 · 59 citations
    2. Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions The Journal of Cell Biology · 2024 · 4 citations
    3. Stem cell apoptosis in HIV‐1 alopecia Journal of Cutaneous Pathology · 2006 · 15 citations
    4. Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways Molecules · 2026
    5. 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis Journal of Investigative Dermatology · 2023
    6. Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells The Journal of Urology · 2008 · 25 citations
    7. 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1 Archives of Biochemistry and Biophysics · 2001 · 4 citations
    8. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin International journal of molecular sciences · 2023 · 1 citations
    9. Immunomodulatory Effects of Platelet-Rich Plasma (PRP) on Neuroinflammation: Insights from B92 Glial Cells Stimulated with Heat-Killed Escherichia coli 2025
    10. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
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