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    Did you mean Caspase-1?
    Glossary Caspase-1

    enzyme activating inflammatory cytokines and inducing cell death

    Caspase-1, also known as Interleukin-1 converting enzyme (ICE), is an enzyme that plays a crucial role in the inflammatory response by activating pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). It is also involved in a form of programmed cell death called pyroptosis, which helps the body fight infections by eliminating infected cells.

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    1. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice Journal of Immunology · 2015 · 59 citations
    2. Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions The Journal of Cell Biology · 2024 · 4 citations
    3. Stem cell apoptosis in HIV‐1 alopecia Journal of Cutaneous Pathology · 2006 · 15 citations
    4. Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways Molecules · 2026
    5. 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis Journal of Investigative Dermatology · 2023
    6. Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells The Journal of Urology · 2008 · 25 citations
    7. 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1 Archives of Biochemistry and Biophysics · 2001 · 4 citations
    8. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin International journal of molecular sciences · 2023 · 1 citations
    9. Immunomodulatory Effects of Platelet-Rich Plasma (PRP) on Neuroinflammation: Insights from B92 Glial Cells Stimulated with Heat-Killed Escherichia coli 2025
    10. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
    11. Vitamin A regulates dermal papilla cell proliferation and apoptosis under heat stress via IGF1 and Wnt10b signaling Ecotoxicology and environmental safety · 2023 · 2 citations
    12. Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis Journal of Investigative Dermatology · 1998 · 28 citations
    13. Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade Jundishapur Journal of Natural Pharmaceutical Products · 2021 · 1 citations
    14. Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss BioMed Research International · 2018 · 9 citations
    15. Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease Pharmaceuticals · 2023 · 17 citations
    16. Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition Stem cell research & therapy · 2023 · 4 citations
    17. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    18. Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis Journal of Pineal Research · 2019 · 46 citations
    19. Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle Journal of Cutaneous Medicine and Surgery · 2002 · 21 citations
    20. From stem cells protection to skin microbiota balance: <i>Orobanche rapum</i> extract, a new natural strategy Journal of cosmetic dermatology · 2018 · 9 citations
    21. The therapeutic promise of apoptosis Science · 2019 · 9 citations
    22. Sexual dimorphism following in vitro ischemia in the response to neurosteroids and mechanisms of injury BMC Neuroscience · 2020 · 6 citations
    23. Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53 BMC Complementary and Alternative Medicine · 2019 · 2 citations
    24. Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition Middle East Fertility Society Journal · 2023
    25. Treatment of androgenetic alopecia by exosomes secreted from hair papilla cells and the intervention effect of LTF Journal of Cosmetic Dermatology · 2023
    26. Network pharmacology analysis and experimental evaluations of YH complex on androgenetic alopecia by regulating the androgenic‐apoptotic axis 2024
    27. A practical guide for the study of human and murine sebaceous glands <i>in situ</i> Experimental Dermatology · 2013 · 56 citations
    28. Androgen responsive genes as they affect hair growth. PubMed · 2001 · 23 citations
    29. Novel Application of Layered Expression Scanning for Proteomic Profiling of Plucked Hair Follicles Dermatology · 2005 · 7 citations
    30. Electric Stimulation at 448 kHz Modulates Proliferation and Differentiation of Follicle Dermal Papilla Cells Cosmetics · 2024