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research Understanding Cancer Cells of Origin in Cutaneous Tumors

1 citations , January 2016 in “Elsevier eBooks”

This review examines the origins and mechanisms of tumor initiation in common skin cancers, but does not present new experimental findings; it emphasizes the need for further research on cancer stem cells.

research 1376 A multi-scale spatial atlas of human skin links cancer cell states to site of origin

April 2023 in “Journal of Investigative Dermatology”

In this study, researchers developed a detailed spatial atlas of healthy human skin and basal cell carcinoma, revealing that basal cell carcinoma likely originates from hair follicles and involves expansion of specific fibroblast subpopulations found in healthy skin.

research Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential

27 citations , May 2024 in “Clinical and Translational Medicine”

This review discusses the origin, characteristics, and therapeutic potential of melanocyte stem cells in skin pigmentation disorders and reports no clinical results.

research Tracing the cellular origin of cancer

232 citations , January 2013 in “Nature Cell Biology”

Understanding where cancer cells come from helps create better prevention and treatment methods.

research Identification of the cell lineage at the origin of basal cell carcinoma

351 citations , February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

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Community Join

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community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 11 months ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Dermatologist told me to quit fin after turning 40

in Finasteride/Dutasteride 194 upvotes 2 years ago

A dermatologist advised a patient to stop taking finasteride (fin) after turning 40 due to potential risk of aggressive prostate cancer. The patient and others in the conversation debated this advice, discussing the relationship between finasteride, prostate cancer, and hair loss, and considering alternatives like topical finasteride.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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Clinics

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