July 2026 in “The Journal of Immunology” This study observed that in both mouse and human models of alopecia areata, T cells exhibit a stress response involving heat shock proteins and other regulatory markers, suggesting their potential as targets for therapeutic intervention in this autoimmune skin disease.
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August 2002 in “Journal of Investigative Dermatology” Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.
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November 2022 in “Clinical and Experimental Dermatology” This study found that individuals with AA have a higher incidence of atopic and autoimmune conditions, suggesting both Th1 and Th2 immune responses may play a role in its development.
January 2023 in “Discovery immunology” T cells and bacteria in the gut and skin help maintain health and protect against disease.
November 2025 in “The Journal of Immunology” This study identified specific genes upregulated in skin γδ T cells involved in alopecia areata, with findings suggesting these cells contribute to disease pathogenesis through inflammatory and Th1 response mechanisms in mouse and possibly human skin.