31 citations,
March 2018 in “Frontiers in Immunology” The document concludes that anti-dsDNA antibodies are not unique to SLE and their use as indicators is doubtful, highlighting the need for better understanding and classification of the disease.
3 citations,
June 2020 in “Open access rheumatology” A patient with Rhupus was diagnosed with Rowell syndrome and treated with various medications.
1 citations,
February 2023 in “International Journal of Rheumatic Diseases” This case-based review analyzed three instances of tuberculosis (TB) mimicking systemic lupus erythematosus (SLE) flare, with patients aged 27 to 32 years. These cases lacked typical SLE features like butterfly erythema, lupus hair, alopecia, or proteinuria. The study found that TB could induce the production of various autoantibodies, such as anti-nuclear and anti-double-stranded DNA antibodies, which are usually seen in SLE. However, these autoantibodies did not change the clinical or radiographic presentation of TB and were not present after the infection resolved. The resistance of SLE-like symptoms to steroid and immunosuppressive treatments suggested an infectious cause. The findings highlight the importance of considering active TB in patients with SLE-like symptoms, especially when specific serological markers and hypocomplementemia are present.
The study on systemic lupus erythematosus (SLE) in India, involving 40 patients, found that the mean age of onset was 23.3 years with a female to male ratio of 19:1. Common skin lesions included malar rash (77.5%), photosensitivity (70%), and non-scarring alopecia (60%). Systemic manifestations frequently observed were arthritis (77.5%) and nephritis (30%). Among patients with only cutaneous manifestations, a significant number had positive serological markers such as antinuclear antibody (85%) and anti-double-stranded DNA (57%). The findings suggest that early identification of SLE through skin lesions and serological profiles can precede systemic symptoms, highlighting the importance of environmental factors in the Indian context.
2 citations,
January 2012 in “PubMed” Mycophenolate mofetil is effective for treating severe lupus nephritis in children.