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      learn capsicum

      • Does capsicum improve scalp circulation or hair growth? Capsaicin dilates blood vessels through TRPV1 activation, so in theory capsicum could raise scalp blood flow (this has not been measured on the scalp in a hair-loss study), but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.

      learn Minoxidil

      Vasodilator used on the scalp and, at low doses, as a tablet

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials