Zwischen Tradition und Innovation Historische Plätze in der Bundesrepublik Deutschland nach 1945
January 2004
epithelial-mesenchymal interactions hair follicle development anagen catagen telogen molecular signals inhibitory signals growth stimulatory pathways apoptosis dermal papilla proteoglycans versican growth stimulators hair growth disorders hair growth phases hair cycle growth phase rest phase involution phase cell death skin connective tissue growth enhancers
TLDR Understanding hair growth phases and signals can help treat hair disorders.
The document discussed the critical role of epithelial-mesenchymal interactions in hair follicle development and the hair cycle, which includes phases of growth (anagen), involution (catagen), and rest (telogen). It highlighted how distinct molecular signals regulate these interactions during each phase, with inhibitory signals predominating in telogen and growth stimulatory pathways activating in anagen. The transition to catagen involves apoptosis in the hair follicle epithelium and quiescence in the dermal papilla. Proteoglycans like versican modulate these signaling exchanges, potentially enhancing or reducing the effects of growth stimulators. The document emphasized the need for further research to translate these findings into clinical applications for treating hair growth disorders.
