Genetic Association Between Polycystic Ovary Syndrome and the APOA5 rs662799 and PLIN1 rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study

    January 2024 in “ Biomarker Insights ”
    Sherin Bakhashab, Asma A. Batarfi, Mahinar M Alhartani … Wessam Mady
    Studysummary This study found significant associations between PCOS susceptibility and specific genetic variants in the APOA5 and PLIN1 genes among Western Saudi women, identifying novel alleles and genotypes that may influence PCOS risk and related clinical characteristics.
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    Research cited in this study 6

    1. MC4R Variants rs12970134 and rs17782313 Are Associated with Obese Polycystic Ovary Syndrome Patients in the Western Region of Saudi Arabia BMC Medical Genetics · 2019
    2. Serum Lipid Profile and Insulin Resistance in Women with Polycystic Ovary Syndrome Journal of Diabetes, Metabolic Disorders & Control · 2018
    3. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    4. Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis Nature Reviews Endocrinology · 2011
    5. Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan BMC Medicine · 2010
    6. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004