Polycystic Ovary Syndrome Is Linked With the Fat Mass Obesity (FTO) Gene Variants rs17817449 and rs1421085 in Western Saudi Arabia

October 2021 in “ Bioinformation ”

Sherin Bakhashab, NULL AUTHOR_ID

Polycystic ovary syndrome PCOS FTO gene rs17817449 rs1421085 rs8050136 hair loss high body mass index BMI homozygous C

TLDR Certain gene variants are linked to a higher risk of polycystic ovary syndrome, hair loss, and obesity in women from western Saudi Arabia.

The study "Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia" involved 95 patients with Polycystic ovary syndrome (PCOS) and 94 control subjects. The research found a significant link between PCOS susceptibility and the FTO gene variants rs17817449 and rs1421085. Additionally, variants rs17817449 and rs8050136 were significantly associated with hair loss in the PCOS group. The variants rs1421085 and rs8050136 were also associated with a high body mass index (BMI>30 kg/m2). The risk alleles in the studied population associated with hair loss and elevated BMI in women with PCOS were homozygous C for rs8050136. This data contributes to understanding the genetic predisposition of PCOS among women in western Saudi Arabia.

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