Polycystic Ovary Syndrome Is Linked With the Fat Mass Obesity (FTO) Gene Variants rs17817449 and rs1421085 in Western Saudi Arabia

    October 2021 in “ Bioinformation ”
    Sherin Bakhashab, NULL AUTHOR_ID
    Image of study
    TLDR Certain gene variants are linked to a higher risk of polycystic ovary syndrome, hair loss, and obesity in women from western Saudi Arabia.
    The study "Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia" involved 95 patients with Polycystic ovary syndrome (PCOS) and 94 control subjects. The research found a significant link between PCOS susceptibility and the FTO gene variants rs17817449 and rs1421085. Additionally, variants rs17817449 and rs8050136 were significantly associated with hair loss in the PCOS group. The variants rs1421085 and rs8050136 were also associated with a high body mass index (BMI>30 kg/m2). The risk alleles in the studied population associated with hair loss and elevated BMI in women with PCOS were homozygous C for rs8050136. This data contributes to understanding the genetic predisposition of PCOS among women in western Saudi Arabia.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 22 results

      community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

      in Treatment  9 upvotes 6 months ago
      OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 2 years ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Sugar and Hair loss connections

      in Research/Science  41 upvotes 10 months ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

    Similar Research

    5 / 1000+ results