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GlossaryHomozygous

having two identical alleles for a specific gene

Homozygous refers to having two identical alleles for a particular gene. In simpler terms, if you inherit the same version of a gene from both your mother and your father, you are homozygous for that gene. This can influence traits such as hair color or susceptibility to certain conditions like alopecia. For example, if both alleles for a gene related to hair growth are the same, it can determine whether you have a full head of hair or are more prone to hair loss.

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Metreleptin Treatment in a Boy with Congenital Generalized Lipodystrophy Due to Homozygous c.465_468delGACT (p.T156Rfs*8) Mutation in the BSCL2 Gene: Results From the First Year

research Metreleptin Treatment in a Boy with Congenital Generalized Lipodystrophy Due to Homozygous c.465_468delGACT (p.T156Rfs*8) Mutation in the BSCL2 Gene: Results From the First Year

1 citations, June 2022 in “JCRPE”

Metreleptin treatment significantly improved metabolic health in a boy with congenital generalized lipodystrophy.

Identification of Factors Contributing to Phenotypic Divergence via Quantitative Image Analyses of Autosomal Recessive Woolly Hair/Hypotrichosis with Homozygous c.736T>A LIPH Mutation

research Identification of Factors Contributing to Phenotypic Divergence via Quantitative Image Analyses of Autosomal Recessive Woolly Hair/Hypotrichosis with Homozygous c.736T>A LIPH Mutation

12 citations, July 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

Different hair fiber development might explain why hair loss severity varies in patients with a specific genetic mutation, and treatments that thicken hair could help.

research Homozygous Whole Body Cbs Knockout in Adult Mice Features Minimal Pathology During Aging Despite Severe Homocysteinemia

7 citations, March 2022 in “The FASEB journal”

Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.

Case Report: Exploring Autosomal Recessive Woolly Hair: Genetic and Scanning Electron Microscopic Perspectives on a Japanese Patient

research Case Report: Exploring Autosomal Recessive Woolly Hair: Genetic and Scanning Electron Microscopic Perspectives on a Japanese Patient

May 2024 in “Frontiers in medicine”

A genetic mutation in the LIPH gene causes tightly curled hair that stops growing in some Japanese individuals.

Case Report: A Novel Splice-Site Mutation of MTX2 Gene Caused Mandibuloacral Dysplasia Progeroid Syndrome: The First Report from China and Literature Review

research Case Report: A Novel Splice-Site Mutation of MTX2 Gene Caused Mandibuloacral Dysplasia Progeroid Syndrome: The First Report from China and Literature Review

March 2024 in “Frontiers in endocrinology”

A new MTX2 gene mutation caused a severe genetic disorder in a young Chinese girl.

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community How to know if shedding is from tren or minoxidil?

in Minoxidil 5 upvotes 8 months ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

community Dutasteride broked my liver (maybe)

in Finasteride/Dutasteride 8 upvotes 2 years ago

A user shared their experience with high cholesterol, glucose, and potential metabolic syndrome after using Finasteride and Dutasteride for hair loss. They plan to improve their health with diet and exercise before considering medication.

community Recently went bald and will stop taking finasteride. Will stop taking it impact density in my beard and eyebrows? Also here’s after and before picture

in Shaved/buzzed 107 upvotes 3 months ago

The user recently went bald and plans to stop taking finasteride, questioning its impact on beard and eyebrow density. Responses suggest he looks good both bald and with thinning hair, with some recommending minoxidil for the crown and noting finasteride's effect on beard thickness.