Histone Deacetylase 1 in Patients With Alopecia Areata and Acne Vulgaris: An Epigenetic Alteration

    January 2022 in “ Australasian Journal of Dermatology ”
    Heba A. Abdelkader, Iman M. Amin, Laila Ahmed Rashed … Marwa Ezzat
    Studysummary This study found that serum HDAC1 levels are significantly higher in patients with alopecia areata compared to those with acne vulgaris and healthy controls, suggesting potential therapeutic opportunities for HDAC inhibitors.
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    Research cited in this study 6

    1. Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes ˜The œjournal of immunology/˜The œJournal of immunology · 2019
    2. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    3. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013
    4. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    5. Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata British Journal of Dermatology · 2011
    6. Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation PLoS ONE · 2007