Molecular Mechanisms of Ectodermal Dysplasia Syndromes

    June 2004 in “ Työväentutkimus Vuosikirja ”
    Johanna Laurikkala
    Studysummary This article reviews the roles of several signaling pathways and molecules, including FGFs, Hh, Notch, TGF, and Wnt, in the development of teeth and hair follicles, but reports no new findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 18

    1. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    2. Identification of a Secreted BMP Antagonist, Ectodin, Integrating BMP, FGF, and SHH Signals from the Tooth Enamel Knot Developmental biology · 2003
    3. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    4. Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin The FASEB Journal · 2003
    5. Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues The EMBO Journal · 2002
    6. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    7. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    8. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    9. Edar/Eda Interactions Regulate Enamel Knot Formation in Tooth Morphogenesis Development · 2000
    10. Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000
    11. Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators Developmental dynamics · 2000
    12. Regulation of a Hair Follicle Keratin Intermediate Filament Gene Promoter Journal of Cell Science · 1998
    13. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    14. Expression and Function of FGFs-4, -8, and -9 Suggest Functional Redundancy and Repetitive Use as Epithelial Signals During Tooth Morphogenesis Developmental dynamics · 1998
    15. Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita Nature Genetics · 1995
    16. Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination ˜The œjournal of cell biology/˜The œJournal of cell biology · 1993
    17. The Secret Life of the Hair Follicle Trends in genetics · 1992
    18. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989

    Related research 1

    1. Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies International reviews of immunology · 2015