Comparison of Spironolactone and Spironolactone Plus Metformin in the Treatment of Polycystic Ovary Syndrome

    September 2015 in “ Gynecological Endocrinology ”
    Halit Diri, Sulbiye Karaburgu, Banu Acmaz … Fahrettin Kelestimur
    Studysummary In this study, spironolactone and spironolactone plus metformin both significantly reduced hirsutism scores in women with PCOS, but the combination therapy was not more effective than spironolactone alone regarding BMI, hormone levels, or insulin resistance.
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    Research cited in this study 12

    1. The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology European Journal of Endocrinology · 2014
    2. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2013
    3. Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study The Journal of Clinical Endocrinology and Metabolism · 2013
    4. Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome European journal of endocrinology · 2009
    5. Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review Endocrine Reviews · 2008
    6. Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials The Journal of Clinical Endocrinology & Metabolism · 2008
    7. Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2008
    8. Finasteride Versus Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism International journal of gynaecology and obstetrics · 2004
    9. A Comparison Between Spironolactone and Spironolactone Plus Finasteride in the Treatment of Hirsutism European journal of endocrinology · 2004
    10. Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2003
    11. The Effect of Metformin on Hirsutism in Polycystic Ovary Syndrome European journal of endocrinology · 2002
    12. The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women Fertility and sterility · 1985