Short-Term, Low-Dose Spironolactone for Treatment of Hyperandrogenic Symptoms of Polycystic Ovary Syndrome: A Systematic Review

    November 2025 in “ Clinical Endocrinology ”
    Telma Martins Viveiros, Neha Deshpande, Irene Karderinis, Yu‐Shui Ma, Sophie Clarke, Vikram Talaulikar, Bassel Wattar
    TLDR Spironolactone and metformin work similarly for PCOS symptoms, but more research is needed.
    Current evidence indicates no significant difference between spironolactone and metformin in treating hyperandrogenic symptoms of polycystic ovary syndrome (PCOS). Despite its off-label status, spironolactone is widely used due to limited safety concerns, particularly for individuals who cannot use hormonal contraceptives. However, larger and higher-quality studies are necessary to confirm its efficacy in managing PCOS.
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