Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

    September 2011 in “ Journal of Dermatological Science ”
    Shigeki Inui, Satoshi Itami
    Studysummary TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.
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    Research cited in this study 2

    1. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    2. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002