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Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

research Androgen receptor transactivity is potentiated by TGF-β1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells

19 citations , September 2011 in “Journal of Dermatological Science”

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

Wound Healing, Cutaneous Therapy, and Hair Growth

research 14. Wound Healing; Cutaneous Therapy; Hair

February 2008 in “Medical & surgical dermatology”

Some treatments like topical oxygen and stem cells show promise for wound healing and hair growth, but evidence for modern dressings over traditional ones is limited.

research Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla

122 citations , November 2010 in “Journal of Dermatological Science”

This study found that increased expression of type II 5α-reductase, androgen receptors, and Hic-5/ARA55 in dermal papilla cells upregulates androgen sensitivity, playing a key role in androgenetic alopecia pathogenesis.

research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles

32 citations , June 2017 in “Journal of Pharmaceutical Sciences”

This study found that coating liquid crystalline nanoparticles with chitosan significantly enhanced the skin permeation of 5α-reductase inhibitors, suggesting a promising strategy for improving topical delivery in androgenetic alopecia treatment.

Abstracts From The 55th European Society Of Human Genetics Conference: Oral Presentations

research Abstracts from the 55th European Society of Human Genetics (ESHG) Conference: Oral Presentations

5 citations , May 2023 in “European Journal of Human Genetics”

This study found that mutations in the TULP3 gene are associated with progressive degeneration of the liver, kidney, and heart in adults, highlighting the importance of early detection and management.

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Learn

1 / 801 results

learn Hair Transplant

Will transplanted hair fall out after a hair transplant? Transplanted hair is permanent but may temporarily shed before new growth occurs.

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Clinics

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Community Join

5 / 7 results

community 5 montsh of treatment with min-fin

481 upvotes 3 months ago

The user experienced noticeable hair regrowth after 5 months using a homemade solution of minoxidil and finasteride, along with moisturizer and tretinoin. They plan to continue the treatment for a year, noting improvements in hair density and appearance.

community Hi-c5 protein, explains why the mechanical tension theory may be correct.

22 upvotes 3 weeks ago

Hair loss may be influenced by mechanical tension and inflammation, with the hi-c5 protein amplifying androgen effects, leading to follicle miniaturization. Treatments like finasteride, minoxidil, and scalp massages are suggested to manage hair loss.

community Just 3 Months Fin/Min, It's working!!! [30M]

214 upvotes 4 months ago

A 30-year-old man saw improved hair density and texture after three months using Minoxidil, Finasteride, and ketoconazole shampoo, despite initial side effects. He experienced increased body hair and libido and is satisfied with the results despite the high cost in Turkey.

community How is this hairline? Doesn't look natural to me (8 months)

in Transplants 221 upvotes 4 months ago

The user is unhappy with their hair transplant results, feeling the hairline looks unnatural, but most commenters reassure them it looks good and natural. Some suggest styling changes or focusing on hair care routines.

community Why do some doctors just lie to our faces ?

22 upvotes 6 months ago

A 19-year-old is frustrated with doctors giving misleading information about hair loss treatments, specifically finasteride and minoxidil. They plan to self-administer finasteride due to concerns about side effects and lack of supportive medical guidance.

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