Urotensin II Promotes the Proliferation and Secretion of Vascular Endothelial Growth Factor in Rat Dermal Papilla Cells by Activating the Wnt-Beta-Catenin Signaling Pathway

June 2023 in “ Italian Journal of Medicine ”

Congjuan Liao, Zhen Huang, Liuting Chen, Xiaorong Fan, Jun Peng, Xiaoqing Tan, Jianshe Yang, Xusheng Zhang

Urotensin II vascular endothelial growth factor VEGF dermal papilla cells DPCs Wnt-β-catenin signaling pathway Wnt inhibitor DKK1 Ki67 PCNA U II Wnt pathway

TLDR Urotensin II increases growth and VEGF production in rat skin cells by turning on the Wnt-β-catenin pathway.

The study investigated the effect of Urotensin II (U II) on the proliferation and secretion of vascular endothelial growth factor (VEGF) in rat dermal papilla cells (DPCs). The results showed that U II increased the mRNA expression of proliferation markers Ki67 and PCNA, and activated the Wnt/β-catenin pathway. However, the Wnt inhibitor DKK1 reversed the effect of U II. Therefore, the study concluded that U II promoted the proliferation and secretion of VEGF in rat DPCs through the activation of the Wnt-β-catenin signaling pathway.

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Urotensin II Promotes the Proliferation and Secretion of Vascular Endothelial Growth Factor in Rat Dermal Papilla Cells by Activating the Wnt-Beta-Catenin Signaling Pathway

research Urotensin II Promotes the Proliferation and Secretion of Vascular Endothelial Growth Factor in Rat Dermal Papilla Cells by Activating the Wnt-Beta-Catenin Signaling Pathway

June 2023 in “Italian Journal of Medicine”

Urotensin II increases growth and VEGF production in rat skin cells by turning on the Wnt-β-catenin pathway.