Treatment of Diseases Associated with Cicatricial Alopecia

    January 2022 in “ Przegla̧d dermatologiczny
    Lidia Rudnicka, Agnieszka Kaczorowska, Anna Waśkiel‐Burnat, Adriana Rakowska, Małgorzata Olszewska
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    TLDR The document concludes that there are various treatments for diseases linked to scarring hair loss, especially for primary scarring alopecia.
    The document discusses cicatricial (scarring) alopecia, a condition that results from perifollicular inflammation that destroys hair follicles and replaces them with connective tissue, or from damage done to follicles by other pathologies not primarily directed against follicles. Examples of such pathologies include cutaneous tuberculosis, favus, and morphea en coup de sabre. Hair follicle atrophy with clinical, trichoscopic, and histological features of follicular drop out can also occur in the very late stage of non-cicatricial alopecia, such as androgenetic alopecia and alopecia areata. The document also mentions a fourth group of diseases with similar clinical and sometimes trichoscopic presentation, but significantly different histology, which is alopecia associated with neoplastic diseases (alopecia neoplastica). The document summarizes basic information about therapeutic methods that can be applied in selected diseases associated with cicatricial alopecia, with particular emphasis on primary cicatricial alopecia.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  98 upvotes 1 month ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 4 months ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  57 upvotes 2 weeks ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Finasteride not working isnt it MPB?

      in Finasteride/Dutasteride  5 upvotes 11 months ago
      A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

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