Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris
April 2020
in “American Journal of Clinical Dermatology”
TLDR
Topical therapies show promise for hair loss and acne treatment with minimal side effects.
The article explores the effectiveness and safety of using topical antiandrogen therapies to treat androgenetic alopecia and acne vulgaris. The therapies include finasteride, ketoconazole shampoo, and cortexolone 17a-propionate (C17P). The authors found that these therapies are promising treatments for male pattern hair loss, especially when used with topical minoxidil. C17P also has potential in treating acne vulgaris in both males and females. Clinical trials have reported minimal adverse effects for all topical therapies. However, more research is needed to determine their effectiveness and safety, particularly in women.
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Cited in this study
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Combination of 0.25% finasteride and 3% minoxidil works better than just 3% minoxidil for increasing hair thickness in women.
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Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.
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research The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis
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research Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia
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Minoxidil and finasteride combo maintains hair density effectively.
research A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers
New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.
research Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: An update of what we now know
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research Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia
research Evaluation and treatment of male and female pattern hair loss
Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.
research Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men
Ketoconazole shampoo with finasteride improves hair density in men with hair loss.
research Treatment of hyperandrogenic alopecia in women
research Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia
Finasteride doesn't effectively treat hair loss in postmenopausal women.
research Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia
research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
research Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course
Topical finasteride helps regrow hair and reduce balding without side effects.
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research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris
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