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research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

7 citations , December 2019 in “American Journal of Clinical Dermatology”

This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.

research Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies

May 2025 in “Journal of the American Academy of Dermatology”

This review highlights the available and investigational anti-androgen treatments for female pattern hair loss in the US, noting their limitations and the potential for fewer systemic side effects with topical options compared to oral medications.

research Role of Topical Ketoconazole in Therapeutic Hair Care Beyond Seborrhoeic Dermatitis and Dandruff

March 2025 in “JEADV Clinical Practice”

This article explores the role of ketoconazole shampoo in hair care beyond treating dandruff and seborrhoeic dermatitis, suggesting it may reduce hair shedding and chronic scalp inflammation, potentially complementing treatments for androgenetic alopecia.

research Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments

March 2026 in “Preprints.org”

This study reviewed evidence for six minimally invasive treatments for androgenetic alopecia, finding consistent support for platelet-rich plasma and topical finasteride, while other options like microneedling and intradermal dutasteride showed promise but need further and standardized research.

research Comprehensive Strategies for the Management of Androgenetic Alopecia: From Conventional Therapies to Nanotechnology and Regenerative Approaches

August 2026 in “Journal of Dermatologic Science and Cosmetic Technology”

In this review, researchers critically examine contemporary treatments for androgenetic alopecia, emphasizing advanced drug delivery systems, regenerative medicine, and emerging molecular targets, while identifying significant gaps that hinder translating these innovations into clinical practice.

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Community Join

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community 8 months of therapies, finasteride, minoxidil and more

in Progress Pictures 397 upvotes 5 months ago

The user experienced significant hair regrowth over 8 months using finasteride, minoxidil, and a custom topical mix including progesterone, cortisone, and alpha 5 estradiol. They reported no side effects and noticed improvement around the third month.

community Scalp tension, massage therapy, and Botox! Let’s talk about it!

1 upvotes 1 month ago

The conversation discusses using adjunct therapies like scalp massage and Botox to enhance the effects of DHT inhibitors for hair loss. It also mentions using GHK-cu, finasteride, keto shampoo, and a natural topical DHT-reducing serum for hair regrowth and reduced shedding.

community When meds don't work how long is too soon before giving up?

7 upvotes 3 weeks ago

A user has been using finasteride, minoxidil, and microneedling for hair loss but continues to experience thinning and has been rejected for a hair transplant due to a thin donor region. They are considering switching to dutasteride and exploring other treatments like mesotherapy, PRP, and topical anti-androgens, while also contemplating shaving their head.

community M29 - 4 YEARS on Dutasteride - almost no progress

6 upvotes 8 months ago

The user has been on a comprehensive hair loss treatment regimen for four years, including Dutasteride, topical and oral Minoxidil, and various other treatments, but has seen little progress and is considering a hair transplant. Despite trying multiple therapies, including PRP and exosome injections, the user is still experiencing hair thinning and is hesitant about trying peptides due to potential cancer risks.

community I Get Side-Effects from Anti-Androgens

8 upvotes 6 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

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Learn

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is an investigational topical androgen-receptor degrader. One 12-week Phase II trial in 180 Chinese men found two of four regimens beat placebo on hair count; it is not approved or available.

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide (KX-826) is an unapproved, investigational topical antiandrogen whose safety data come from short-term sponsor announcements, not peer-reviewed studies. No study has compared it with finasteride, so there is no evidence that it is safer.
What is pyrilutamide, and how does it help with androgenic alopecia or hair loss caused by DHT? Pyrilutamide (KX-826) is an investigational topical antiandrogen designed to block DHT at the androgen receptor in the scalp. Its sponsor reported that a 2023 China Phase III of a 0.5% tincture did not beat placebo and that a 2026 Phase III stage of a 1.0% tincture did; none of the data are peer-reviewed and it is not approved as a medicine anywhere.
Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in men and women but is not approved for hair loss anywhere. Its sponsor reports one failed (2023) and one successful (2026) Phase III in men, none of it peer-reviewed; long-term safety is unknown, and anti-androgens are not considered appropriate in pregnancy.

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

learn RU58841

Experimental topical anti-androgen sold as a research chemical

learn Exosomes

What does Fluridil do on the scalp, and how does it block the DHT hormone? Fluridil is a topical anti-androgen sold in some European countries. One small 2002 trial led by its developer reported more hairs in the growth phase; it is not FDA-approved and the evidence is limited.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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