Therapeutic Peptides in Skin and Hair Disorders

January 2022

Nikhila Leemon, S. S. Raga, V. S. Soumya, Sreejith Parameswara Panicker

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Research cited in this study

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research Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth

8 citations , September 2021 in “EMBO Molecular Medicine”

This study found that a 5-mer peptide called P5 promotes hair growth by activating adiponectin receptor 1, suggesting its potential use as a topical treatment for alopecia.

$The Role of Platelet-Rich Plasma Therapy in Refractory Folliculitis Decalvans$

research The Role of Platelet-Rich Plasma Therapy in Refractory Folliculitis Decalvans

5 citations , April 2021 in “JAAD Case Reports”

This article discusses the characteristics and histopathology of folliculitis decalvans and reports no clinical results, highlighting the need for further research to understand its causes.

research The Utility of Platelet-Rich Plasma for the Treatment of Alopecia

6 citations , June 2020 in “Journal of Drugs in Dermatology”

This review discusses the use of platelet-rich plasma for treating various types of alopecia, reporting promising preliminary hair regrowth results but noting a lack of quantitative evidence from well-designed clinical trials.

research Randomized Controlled Trial on a PRP-Like Cosmetic with Biomimetic Peptides for the Treatment of Alopecia Areata

8 citations , December 2018 in “Journal of Dermatological Treatment”

This study found that a PRP-like cosmetic product called TR-M-PRP plus significantly improved hair growth in individuals with alopecia areata over three months, as measured by the SALT score, suggesting it could be a safer alternative to traditional PRP treatments.

research Meta-Analysis on Evidence of Platelet-Rich Plasma for Androgenetic Alopecia

29 citations , January 2018 in “International Journal of Trichology”

This meta-analysis reported that platelet-rich plasma injections for androgenetic alopecia may increase hair number and thickness locally, but further studies are needed to establish their overall effectiveness.

research Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders

2 citations , February 2017 in “International Journal of Molecular Sciences”

This study found that Erdr1 expression was significantly reduced in the skin of patients with hair loss disorders, particularly alopecia areata, suggesting it may serve as a novel biomarker.

research A Split Head Study of Efficacy of Placebo Versus Platelet-Rich Plasma Injections in the Treatment of Androgenic Alopecia

33 citations , January 2017 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections improved hair density, quality, and thickness in males with androgenic alopecia compared to placebo, with reported high patient satisfaction and no major side effects.

research Cosmeceuticals: Peptides, Proteins, And Growth Factors

67 citations , May 2016 in “Journal of Cosmetic Dermatology”

This study describes commonly used peptides, proteins, and growth factors in cosmeceuticals and discusses their potential benefits in dermatology, though their long-term effects remain unconfirmed.

Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

research Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

36 citations , April 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

This article reviews the role of vasoactive intestinal peptide in maintaining immune privilege in hair follicles and does not report new findings; the authors propose it as essential for immune homeostasis in alopecia areata.

Lack of Collagen VI Promotes Wound-Induced Hair Growth

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.

research Possibilities And Limitations For Reversal Of Age-Related Hair Loss

2 citations , January 2010