The effect of minoxidil on endothelial cells

June 1989 in “ Cell Biology International Reports ”

William D. Norris, Graham Johnson, G. F. Donald

TLDR Minoxidil temporarily stops endothelial cell growth without major changes in protein production or movement.

The study from 1989 investigated the effects of minoxidil on cultured endothelial cells, revealing that it temporarily halted cell proliferation in a reversible manner and affected cell morphology depending on the dose. However, minoxidil did not significantly change protein synthesis or inhibit cell migration. The findings highlighted similarities in the response of endothelial cells, keratinocytes, and dermal fibroblasts to minoxidil, while showing differences compared to dermal papilla cells, follicular root sheath fibroblasts, and neutrophils.

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Research cited in this study

8 / 8 results

research Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture

23 citations , March 1988 in “Biochemical Pharmacology”

Minoxidil stops cells from making prostacyclin, which may help with hair growth. More research is needed.

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

63 citations , September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica

24 citations , February 1987 in “Drugs”

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations , December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

96 citations , October 1981 in “Drugs”

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

research Treatment of Severe Hypertension with Minoxidil: Advantages and Limitations

37 citations , April 1979 in “The Journal of Clinical Pharmacology”

Minoxidil effectively controls blood pressure but side effects may limit its use.

research Pharmacologic Properties of Minoxidil: A New Hypotensive Agent

55 citations , March 1973 in “PubMed”

Minoxidil is a new drug that lowers blood pressure.

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