Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity

    September 2025 in “ Immunological Reviews ”
    Inta Gribonika
    TLDR The skin can independently form immune responses through special structures, offering new ways to treat skin diseases.
    The study highlights the skin's ability to independently form protective immune responses through dermal tertiary lymphoid organs (TLOs), which function similarly to germinal centers in lymph nodes. These TLOs provide humoral immunity without relying on inflammatory signals, facilitated by interactions with the skin's microbiota. This discovery suggests a significant role for TLOs in skin immunity and opens new avenues for understanding and treating skin diseases by focusing on non-inflammatory host-microbiota interactions. The findings emphasize the potential for innovative skin health care solutions by leveraging these local immune responses.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    5 / 5 results

      community PP405 is nothing but a scam and Pelage know it.

      in Chat  78 upvotes 3 months ago
      PP405 is criticized for overhyped claims and cherry-picked data, with doubts about its effectiveness compared to minoxidil and finasteride. Many users express skepticism, emphasizing the need for more comprehensive trial results.

      community How to Keep Your Hair on Steroids

      in Treatment  26 upvotes 1 year ago
      To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

      community Minoxidil seems logistically impossible and impractical to use

      in Minoxidil  136 upvotes 2 years ago
      The post discusses concerns about the practicality of using Minoxidil foam for hair loss, including the frequency of application, preparation, coverage area, and drying time. Responses suggest that missing a dose isn't detrimental, it can be applied once a day, it works on all hair areas, and it doesn't need to be perfectly dry before application.

      community Black Hair Regrowth Process Timeline

      in Progress Pictures  70 upvotes 3 years ago
      Treating Black/ethnic hair loss with a combination of Minoxidil, finasteride, Nizoral shampoo and derma pen treatments, as well as occasional Jamaican Black Caster Oil use. The user documented their progress over the course of 3.5 months, showing improvement in hair growth.

    Similar Research

    5 / 1000+ results