Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity

    September 2025 in “ Immunological Reviews ”
    Inta Gribonika
    TLDR The skin can independently form immune responses through special structures, offering new ways to treat skin diseases.
    The study investigates the role of tertiary lymphoid organs (TLOs) in the skin's humoral immunity, revealing that these structures can independently support antibody production, even in the absence of lymph nodes. TLOs facilitate organized immune responses against microbiota like Staphylococcus epidermidis and can persist due to continuous antigen availability. The research highlights the skin's unique ability to adapt to microbial symbiosis, suggesting potential for therapeutic strategies such as topical vaccination and immunotherapy. Additionally, the study explores the use of engineered skin commensals to enhance immunity and develop novel vaccination methods, while also discussing the development of ex vivo human skin models to replace animal testing in therapy development.
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