Genomic and Anatomical Comparisons of Skin Support Independent Adaptation to Life in Water by Cetaceans and Hippos
April 2021
in “
Current Biology
”
Research cited in this study
4 / 4 resultsresearch Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals
This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.
research Anti-Inflammatory Role of 15-Lipoxygenase Contributes to the Maintenance of Skin Integrity in Mice
In this study, Alox15 knockout mice exhibited disrupted skin integrity and increased inflammation, suggesting that Alox15-mediated resolvin D2 production is crucial for maintaining skin homeostasis by suppressing inflammation.
research Regional Variations in the Histology of Porcine Skin
This study found that while porcine skin resembles human skin, there are significant regional differences in skin composition and morphology, which could affect its use as a human analogue in research.
research Increased Rate of Hair Keratin Gene Loss in the Cetacean Lineage
This study highlights the loss of hair-type keratin genes in cetaceans compared to terrestrial mammals, suggesting a potential adaptive role linked to their hairless phenotype and habitat changes.
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In this study, the researchers reported extensive gene loss and high pseudogenization rates of α-keratin genes in cetaceans compared to terrestrial mammals, likely linked to hair loss and aquatic adaptations.
research Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals
This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.
research Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans
This study found that cetaceans have adapted their fibroblast growth factors to assist in low bone density, hypoxia tolerance, and the development of rigid flippers, reflecting significant evolutionary changes for aquatic life.
research Increased rate of hair keratin gene loss in the cetacean lineage
This study highlights the loss of hair-type keratin genes in cetaceans compared to terrestrial mammals, suggesting a potential adaptive role linked to their hairless phenotype and habitat changes.
research Decay of Skin-Specific Gene Modules in Pangolins
This study explored the molecular biology of skin adaptations in pangolins, revealing that certain genes for lipid synthesis have inactive patterns, while others related to skin function remain intact, suggesting complex evolutionary changes in their skin physiology.