TLDR Reducing IGF-1 can help rejuvenate hair follicles and prevent hair graying and loss.
The study explores the role of IGF-1 in hair follicle aging, demonstrating that elevated IGF-1 levels induce cellular senescence, leading to premature hair graying and loss in mice. Transgenic mice overexpressing IGF-1 showed disrupted hair follicle homeostasis, with increased p53 activity being crucial. Interventions targeting IGF-1 signaling, such as SIRT1 overexpression, senolytics (dasatinib and quercetin), and dietary restriction (DR), reduced senescence markers and restored hair follicle stem cell functionality. These findings suggest that targeting IGF-1-induced senescence could be a potential strategy for rejuvenating hair follicles and improving tissue health.
7 citations,
August 2023 in “Ageing Research Reviews” More research is needed to understand hair aging and develop effective treatments.
3 citations,
July 2023 in “International journal of molecular sciences” Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.
35 citations,
January 2017 in “Journal of Dermatological Science” Stress can cause early aging in certain skin cells, leading to problems with hair growth.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
1 citations,
March 2015 in “Journal of Visualized Experiments” Researchers developed a new, precise method to measure hair loss in mice using image analysis.
205 citations,
March 2012 in “Science Translational Medicine” PGD2 stops hair growth and is higher in bald men with AGA.
199 citations,
April 2010 in “Nature” A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
105 citations,
April 2005 in “Cell” Hair graying happens because certain cells aren't maintained properly.
22 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Fisetin, a type of polyphenol, may help hair grow by increasing certain protein activities in cells.
19 citations,
July 2018 in “Mechanisms of Ageing and Development” Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.
3 citations,
May 2021 in “Evidence-based Complementary and Alternative Medicine” Some traditional Chinese medicines may have anti-aging benefits and could help with hair growth, but more research is needed.
June 2024 in “Regenerative Therapy” Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.
5 citations,
October 2022 in “Cosmetics” Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.
