Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

March 2025 in “ Aging Cell ”

Yang Wang, Jian Yang, Yue Luo, Zhiqiang Zhao, Yawen Yuan, Juan Li, Liu Yang, Yong Yi, Xiaoke Xu, Yang-Zheng Lan, Juan Zou, Qintong Li, Liang Wang, Yang Pan, Yuan‐Han Yang, Muzhao Xiong, Min Wu, Jinsong Li, Weiyuxin Li, Yujun Zhang, Yang Cao, Yi Zhu, Zhi‐Xiong Jim Xiao

IGF-1 cellular senescence hair follicle aging p53 SIRT1 senolytics dasatinib quercetin dietary restriction hair follicle stem cell insulin-like growth factor 1 DR

TLDR Reducing IGF-1 can help rejuvenate hair follicles and prevent hair graying and loss.

The study explores the role of IGF-1 in hair follicle aging, demonstrating that elevated IGF-1 levels induce cellular senescence, leading to premature hair graying and loss in mice. Transgenic mice overexpressing IGF-1 showed disrupted hair follicle homeostasis, with increased p53 activity being crucial. Interventions targeting IGF-1 signaling, such as SIRT1 overexpression, senolytics (dasatinib and quercetin), and dietary restriction (DR), reduced senescence markers and restored hair follicle stem cell functionality. These findings suggest that targeting IGF-1-induced senescence could be a potential strategy for rejuvenating hair follicles and improving tissue health.

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research A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

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