Efficacy and Tolerability of 6-Month Treatment with Tamsulosin Plus Hexanic Extract of Serenoa Repens Versus Tamsulosin Plus 5-Alpha-Reductase Inhibitors for Moderate-to-Severe LUTS-BPH Patients: Results of a Paired Matched Clinical Study

    June 2022 in “ Journal of Clinical Medicine ”
    Antonio Alcaraz, David Castro‐Díaz, Mauro Gacci … on behalf of the QUALIPROST Study Group
    Studysummary This study found that for men with moderate-to-severe LUTS/BPH, 6 months of treatment with tamsulosin plus the hexanic extract of S. repens was as effective as tamsulosin plus a 5-alpha-reductase inhibitor but had better tolerability.
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    Research cited in this study 9

    1. Ejaculations and Benign Prostatic Hyperplasia: An Impossible Compromise? A Comprehensive Review Journal of Clinical Medicine · 2021
    2. The Risk of Venous Thromboembolism in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors Clinical Epidemiology · 2021
    3. Association Between 5-Alpha Reductase Inhibitor Use and the Risk of Depression: A Meta-Analysis Urology Journal · 2020
    4. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm The World Journal of Men's Health · 2020
    5. Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis International Journal of Andrology · 2017
    6. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    7. 5α-Reductase Inhibitors Increase Acute Coronary Syndrome Risk in Patients with Benign Prostate Hyperplasia Journal of Endocrinological Investigation · 2015
    8. A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia Clinical endocrinology · 2014
    9. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003