Successful Therapy of Alopecia Universalis Using a Combination of Systemic Methotrexate and Corticosteroids and Topical 5% Minoxidil

    January 2022 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Kartika Ruchiatan, Erda Avriyanti, Reti Hindritiani, Diah Puspitosari, Oki Suwarsa, Hendra Gunawan
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    TLDR A mix of methotrexate, corticosteroids, and topical minoxidil effectively treated severe total body hair loss, but caused stretch marks and needs long-term monitoring.
    This case report discusses the successful treatment of a 19-year-old man with alopecia universalis (AU) using a combination of systemic methotrexate and corticosteroids, along with topical 5% minoxidil. AU is a severe form of alopecia areata characterized by total hair loss on the entire body. Previous treatments had only provided temporary improvement, but after nine months of combination therapy, the patient experienced significant hair growth and a decrease in the severity of alopecia. The treatment was well-tolerated, although stretch marks appeared on the patient's trunk. This case report suggests that the combination of systemic methotrexate, corticosteroids, and topical minoxidil can be an effective treatment option for AU, but long-term monitoring of treatment and side effects is recommended.
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