Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

    September 2008 in “ Biological & Pharmaceutical Bulletin ”
    Yoshiyuki Mukai, Tatsuya Higashi, Yukiko Nagura, Kazutake Shimada
    Image of study
    TLDR Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.
    This study examined the effects of finasteride on rat brain neurosteroid levels and metabolism. The study found that a 10 mg/kg dose of finasteride can almost completely deplete allopregnanolone in the rat brains, and 20α-DHP is enhanced when the 5α-reduction pathway is inhibited during the PROG metabolism in the brains. However, no change was found in the brain level of 3α-DHP by the administration of finasteride.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Finasteride does deplete important nuero-active steroids

      in Research/Science  9 upvotes 2 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community risks with finasteride and dutasteride

      in Research/Science  140 upvotes 3 months ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

      community Six months of only Dermarolling

      in Progress Pictures  157 upvotes 2 years ago
      User tried dermarolling for hair loss and shared progress pictures. Some suggest adding finasteride and minoxidil, while others debate effectiveness and frequency of dermarolling.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

    Related Research

    6 / 6 results