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research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations, September 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain

33 citations, December 2015 in “Neuroendocrinology”

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

research Inhibition of 5α-Reductase Alters Pregnane Metabolism in the Late Pregnant Mare

7 citations, January 2018 in “Reproduction”

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model

31 citations, November 2014 in “Investigative Ophthalmology & Visual Science”

A natural steroid in the body may protect against eye damage in glaucoma.

research Identification of MicroRNAs Involved in Growth Arrest and Cell Death in Hydrogen Peroxide-Treated Human Dermal Papilla Cells

12 citations, April 2014 in “Molecular Medicine Reports”

Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

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Community Join

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community Minoxidil Sulfate makes everyone a responder

in Research/Science 257 upvotes 1 month ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Oral min vs topical comparison

in Treatment 10 upvotes 2 months ago

Oral minoxidil is claimed to be more effective and easier to use than topical minoxidil, with a 100% response rate, but it may cause unwanted body hair growth and has potential heart-related side effects. Topical minoxidil is less effective for many due to enzyme limitations, can cause scalp issues, and is more challenging to apply, but it avoids systemic side effects.

community 10 months on fin and hairline destroyed.

in Finasteride/Dutasteride 46 upvotes 5 months ago

A user experienced severe hair shedding and hairline recession after 10 months on finasteride. They are considering switching to dutasteride or adding minoxidil.

community 1.5 years fin plus almost 3 years min, I think I’ve definitely made progress but I’m still not where I want to be, advice?

in Progress Pictures 130 upvotes 11 months ago

The user has been using finasteride for 1.5 years and minoxidil for almost 3 years for hair loss, and has seen some maintenance of hair but not significant regrowth. Suggestions from others include switching to dutasteride, trying oral minoxidil, and considering microneedling or hair fibers for better appearance.

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